The Response of Nanotube Field Effect Transistors to Adsorped Protein [ Matthew Leyden ] Electronic detection of single molecule

Abstract [1]: Carbon nanotube field effect transistors have been shown to be effective low concentration biosensors. Low detection limits are important because it allows for early detection of diseases like cancer. The response of nanotubes to adsorped protein is still not fully understood, and we are investigating this response as a function of flow rate, concentration of protein, and dimensionality of the nanotube sensor. We have used polylysine adsorption as a model system to compare theoretical predictions with experiment
Abstract [2] Observing single molecule dynamics at fast time scales is crucial to the study of enzyme function. The time resolution of current single molecule techniques is limited to millisecond time scales, significantly limiting the questions these techniques can address. A defect site in a carbon nanotube lattice dominates the electronic properties and can act as a high temporal resolution charge sensor probing volumes down to a cubic nanometer. We have intentionally created such defects in otherwise pristine carbon nanotube field-effect transistors. I will present electrostatic simulations of the enzyme DNA polymerase tethered to such a defect. The simulations show that as the protein undergoes conformational change a detectable signal will be observable in the nanotube's resistance.