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Two of the principal challenges in biomedical nanoscience and personalized medicine are: a) the detection of disease at the earliest possible time prior to its ability to cause damage (diagnostics and imaging) and b) delivering treatment at the right place, at the right time whilst minimizing unnecessary exposure (targeted therapy with a triggered release). The former is dominated by optical methods, emerging “life on a chip” systems and the versatile magnetic resonance imaging technology. The latter remains an ongoing challenge.