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Protein trafficking is critical in neurons since neurons must orchestrate the movement of a plethora of discrete intracellular signaling proteins from the cell body to the ends of their axons, over distances that may span up to several meters. A problem in studying protein trafficking has been a lack of tools to visualize the movement of discrete proteins inside live neurons, in real time. An integrated understanding of endocytic trafficking at the level of single or small numbers of receptor complexes inside live cells is currently hampered by technical limitations.